Euroanesthesia 2012
European Society of Anesthesiologists
Paris, France
June 11, 2012; 4-5:30pm
Moderators
Evers, Alex S.
Jevtovic-Todorovic, Vesna
Charlottesville, United States
Speakers
Anesthesia-induced developmental neurotoxicity: mechanism and protection
Jevtovic-Todorovic, Vesna, Charlottesville, United States
Anesthetic Related Neurotoxicity in Children: What do we tell the parents?
Flick, Randall, Rochester, United States
General anesthesia injures the developing brain of non-human primates
Brambrink, Ansgar, Portland, United States
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Sunday, May 20, 2012; 8-8:55am
Presenter: Peter J. Davis, MD, SmartTots Affiliate Advisory Council Member, Anesthesiologist-in-Chief, Children's Hospital of Pittsburgh, Professor of Anesthesiology & Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Learner Objectives: After participating in this activity, the learner will be able to: (1) Assess the issues of anesthesia related neurotoxicity in children; (2) Review the pathophysiology of sleep apnea in children; and (3) Review the anesthetic management of children with sleep apnea.
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Friday, May 18, 2012; 3-4:30pm
Speakers
Dhanesh K. Gupta, MD: The Pharmacy is out of Fentayl Again. What Do I Do?
Vesna Jevtovic-Todorovic, MD, PhD, MBA: Developmental Neurotoxicity: Are the Narcotics Safe?
Mohamed A. Naguib, MB, BCh, MSc, FFARCSI, MD: An Emerging Paradigm in Neuropathic Pain: Targeting the Inflamed Glial Cells
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Sunday, May 20, 2012; 1-2:30pm
Moderator
Randall Flick, MD, MPH, Affiliate Advisory Council Member, SmartTots, Associate Professor of Anesthesiology, Mayo Clinic, Rochester, Minnesota
Panelists
Anesthesia and the Developing Brain: What are Our Options?
Vesna Jevtovic-Todorovic, MD, PhD, MBA, Scientific Advisory Board Member, SmartTots, Professor of Anesthesiology
and Neuroscience, University of Virginia Health System, Charlottesville, Virginia
Learner Objectives: After participating in this activity, the learner will be able to: (1) Identify the mechanisms responsible for anesthesia-induced developmental neurotoxicity; (2) Focus on most vulnerable cellular targets responsible for anesthesia-induced neuronal death; and (3) Assess possible protective strategies which would enable safe use of anesthesia in our youngest patients.
Preclinical Neurotoxicity Assessments of Pediatric Anesthetics: Translational Approaches Using a Nonhuman Primate Model
Merle Paule, PhD, Scientific Advisory Board Member, SmartTots and Director, Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas
Learner Objectives: After participating in this activity, the learner will be able to: (1) Describe the vulnerable periods during the rapid growth of the brain during which general anesthetics are likely to have their most deleterious effects in rodent and primate models of development; (2) Describe the duration (weeks, months, years) over which the adverse effects of developmental exposures to general anesthesia on cognitive function have been shown to manifest in animal models; and (3) Describe in general the kinds of cognitive deficits that have been observed in animal models after single, albeit prolonged, episodes of general anesthesia during the brain growth spurt.
Topic Title: TBD
Andrew J. Davidson, MBBS, MD, FANZCA, Affiliate Advisory Council Member, SmartTots, Department of Anaesthesia and Pain Management, The Royal Children’s Hospital Melbourne, Victoria, Australia
What is Needed to Resolve the Question of Whether Animal Studies Apply to Children?
David O. Warner, MD, Affiliate Advisory Council Member, SmartTots, Professor of Anesthesiology, Mayo Clinic, Rochester, Minnesota
Learner Objectives: After participating in this activity, the learner will be able to: (1) Articulate the concept of translation as applied to the relationship between model and human studies; (2) Analyze the strengths and weaknesses of various study designs in this area; and (3) Formulate a conceptual research agenda to resolve this question.
World Congress of Anaesthesiologists
World Federation of Societies of Anaesthesiologists
La Rural, Predio Ferial de Buenos Aires, Argentina
March 27, 2012; 11:00am-1:00pm
Chair and Introduction
Saager, Leif (USA)
Discussion
Absalom, Anthony (The Netherlands): Mechanisms of Neurotoxicity in the Developing Brain
Stapelberg, Francois (New Zealand): Measurements of Cognitive Function
Struys, Michel (The Netherlands): Delirium
EURO-NEURO 2012: 7th International Update on Interdisciplinary Neuroscience
Altes AKH - University of Vienna, Vienna, Austria
February 17, 2012; 9:00-10:30
Chairs
Peter Andrews, UK
Andrew Maas, Belgium
Speakers
Kristin Engelhard, Germany: Are Anesthetics Neurotoxic in Neonates?
Alfons Hammerle, Austria: Xenon and the Brain - Is there a Protective Effect?
Jonathan Rhodes, UK: Promising Neuroprotectants, particularly Progesterone
Pedro Amorim, Portugal: Cerebral Protection during Brain Surgery - Improvement of Current Models
World Congress of Anaesthesiologists
World Federation of Societies of Anaesthesiologists
La Rural, Predio Ferial de Buenos Aires, Argentina
March 27, 2012; 8:30-10:30 am
Chair
Eckenhoff, Roderic (USA)
Speakers
Developmental Neurotoxicity: Todorovic, Vesna (USA)
Calcium Dysregulation: Wei, Huafeng (USA)
Neuroinflammation: Eckenhoff, Roderic (USA)
Perioperative Tauopathy (neurodegenerative illnesses): Whittington, Robert (USA)
Anesthesiology 2011
American Society of Anesthesiologists
McCormick Place Complex, Chicago, Illionis
October 15, 2011; 2:45 PM - 4:45 PM
LEARNER OBJECTIVES:
- Describe the current clinical and preclinical research suggesting that anesthetic exposure may be toxic to the developing brain
- Review the perspective of the US. Food and Drug Administration and its role in ensuring the safety of anesthetic agents
- Discuss insight into potential changes in practice that may result from ongoing research and public concerns related to the safety of anesthetics in children
Moderator
Mervyn Maze, M.B., B.Ch.
University of California, San Francisco, San Francisco, California
Speaker-PreClinical/Clinical
Sulpicio G. Soriano, M.D.
Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts
Speaker-The FDA Perspective
Bob Rappaport, M.D.
Food and Drug Administration, Silver Spring, Maryland
Speaker-Does This Change Your Practice
Dean B. Andropoulos, M.D.
Texas Children's Hospital - Baylor College of Medicine, Houston, Texas
Society for Pediatric Anesthesia's 25th Annual Meeting
Hyatt McCormick Place, Chicago, Illinois
October 14, 2011; 1:30 - 3:00pm
The Past: Ether, Pancuronium and Oxygen
George Gregory, MD
- Understand the basis of modern anesthesia
- Recall how care then transitioned to present day care
- Discuss the history of some anesthetic drugs and anesthesia care
The Present: Inhalational - Neurotoxicity
Sol Soriano, MD
- Understand the sentinel laboratory reports that are the basis of anesthetic-induced developmental neurotoxicity
- Determine if the laboratory findings can be extrapolated to the care of pediatric patients
The Present: Opioids
Myron Yaster, MD
- Understand the neurobiology and neurophysiology of pain in the newborn
- Understand the use of opioids, local anesthetics, and vapors alone in combination in newborn anesthesia
The Future: Safe and Effective Alternatives for Sedation and General Anesthesia in Neonates
Mervyn Maze, MB, ChB
- Understand mechanism and uses for sedative properties of dexmedetomidine
- Understand mechanism and uses for xenon anesthesia
May 23, 2011; 1-4PM
Location
IARS
2011 Annual Meeting
Westin Bayshore Hotel
1601 Bayshore Drive
Vancouver, BC, V6G 2V4, Canada
Agenda
The panel, to be led by SmartTots Scientific Advisory Board Member Vesna Jevtovic-Todorovic, MD, PhD, will discuss recent studies relating to the effects of anesthetics on the developing brain and the potential implications of these findings. The Panel will be accompanied by poster presentations, including late-breaking abstracts.
Panel Speakers
Randall Flick, MD, MPH
Affiliate Advisory Board Member, SmartTots
Associate Professor of Anesthesiology
Mayo Clinic
Laszlo
Vutskits, MD, PhD
Head, Neuroscience-oriented Anesthesia Research Group
Staff Scientist, Pediatric Anesthesia Unit
Geneva University Hospital
Merle
Paule, PhD
Scientific Advisory Board Member, SmartTots
Director, Division of Neurotoxicology
National Center for Toxicological Research (NCTR)
Greg Stratmann, MD, PhD
IARS 2009 Clinical Scholar Research Award Recipient
University of California, San Francisco
March 10, 2011; 8AM – 4PM EST
Location
FDA White Oak Campus
Building 31, the Great Room
White Oak Conference Center (Rm. 1503)
10903 New Hampshire Avenue, Silver Spring, MD
Agenda
The committee will: (1) receive updates regarding neurodegenerative findings (findings related to degeneration in the nervous system) in juvenile animals exposed to anesthetic drugs, as well as results from human epidemiological studies using anesthesia in children (information related to studies of patterns and causes of disease); (2) discuss the relevance of these findings to pediatric patients and provide guidance for future preclinical and clinical studies; and (3) discuss the potential implications of these data upon the practice of pediatric anesthesia as well as the communication of the risk of sedative/anesthetic agents to prescribers and parents.
