IARS 2013 Annual Meeting, San Diego, CA
May 6, 2013 | 8:00 – 9:30 am | Sheraton Hotel & Marina, San Diego
Moderator: Ken B. Johnson, MD
Panelists:
Early Brain Development and Anesthesia Exposure: Do We Have All The Answers?
Vesna Jevtovic-Todorovic, MD, PhD, MBA, Harold Carron Professor of Anesthesiology and Neuroscience, University of Virginia Health System, Charlottesville, Virginia, Scientific Advisory Board Member, SmartTots
Learner Objectives: After participating in this activity the learner will be able to: (1) Summarize new anesthetic drug development activity; (2) Review their mechanism of action; and (3) Discuss what makes them “new” and potential advantages over existing anesthetics.
Update in Neuromuscular Blockade Reversal
Mohamed Naguib, BCh, MSc, FARCSI, MD, Professor of Anesthesiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio
Learner Objectives: After participating in this activity the learner will be able to: (1) Discuss mechanisms of neuromuscular blockade reversal; (2) Summarize recent clinical studies and meta analyses reporting efficacy and risk; and (3) Discuss advantages and disadvantages of various neuromuscular blockade reversals.
What’s in the Drug Development Pipeline for Anesthesia?
Ken B. Johnson, MD, Professor, Department of Anesthesiology, University of Utah, Salt Lake City, Utah
Learner Objectives: After participating in this activity the learner will be able to: (1) Discuss key issues regarding animal data on anesthetic neurotoxicity in the developing brain; (2) Summarize the retrospective clinical studies of neurobehavioral outcomes after infant anesthesia; and (3) Discuss the limitations of both the animal and human data.
Learn more about the IARS 2013 Annual Meeting and ISAP panel.
IARS 2013 Annual Meeting, San Diego, CA
May 5, 2013 | 2:00 – 3:30 pm | Sheraton Hotel & Marina, San Diego
Moderator: Dean B. Andropoulos, MD, MHCM, Chief of Anesthesiology, Texas Children’s Hospital, Professor, Anesthesiology and Pediatrics, Baylor College of Medicine, Houston, Texas; Scientific Advisory Board Member, SmartTots
Panelists:
Vesna Jevtovic-Todorovic, MD, PhD, MBA, Harold Carron Professor of Anesthesiology and Neuroscience, University of Virginia Health System, Charlottesville, Virginia, Scientific Advisory Board; Member, SmartTots
- Update in Mechanisms of Neurotoxicity and Neuroprotective Strategies
- Mitochondria and PPX Neuroprotection
Learner Objectives: After participating in this activity, the learner will be able to: (1) Identify presently available evidence regarding the mechanisms responsible for the neurotoxic effects of general anesthesia on the developing rat brain; and (2) Evaluate protective strategies that could alleviate anesthesia induced neurotoxic side effects.
Sulpicio G. Soriano, III, MD, Boston Children’s Hospital Endowed Chair in Pediatric Neuroanesthesia, Professor of Anaesthesia, Harvard Medical School, Boston, Massachusetts
- Effects of Surgical Stimulus in Animal Models
- Ketamine in Neonatal Rat Model With Surgical Stimulus
Learner Objective: After participating in this activity, the learner will be able to: (1) Review the relevance of concurrent pain and surgical stimulus on the modulation of anesthetic induced neuroapoptosis.
Ansgar M. Brambrink, MD, PhD, Professor of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon
- New Studies of Anesthetic Neurotoxicity in the Infant Rhesus Monkey
- Importance of Primate Studies; Ketamine and Isoflurane in Clinical Doses; Plans for Long Term Follow-up Studies
Lena S. Sun, MD, Professor of Anesthesiology and Pediatrics and Chief, Division of Pediatric Anesthesiology at Columbia University Medical Center, New York, New York
- Does the Scientific Data Warrant a Change in Pediatric Anesthesia Practice?
- Review of PANDA and Other Data and Recommendations for Practice Now
Learner Objectives: After participating in this activity, the learner will be able to: (1) Review clinical studies related to anesthetic neurotoxicity and summarize their main findings; (2) Review ongoing clinical studies in neurodevelopmental outcome after early childhood exposure; and (3) Discuss whether evidence supports changes in clinical practice.
Learn more about the 2013 IARS Annual Meeting and SmartTots panel.
IARS 2013 Annual Meeting, San Diego, CA
May 4, 2013 | 1:30 – 3:00 pm | Sheraton Hotel & Marina, San Diego
James G. Ramsay, MD, Professor of Anesthesiology and ICU, University of California, San Francisco, California; IARS Executive Committee and Past Chair; SmartTots Steering Committee
- What is SmartTots and what is its vision?
- How is IARS addressing research questions of neurotoxicity in infant brains?
- Review of the FDA workshop and consensus statement
- Future developments
LEARNER OBJECTIVES: After participating in this activity, the learner will: (1) Be aware of the laboratory evidence of apoptosis of GABA-based anesthetics in newborn animals; (2) Review the epidemiological evidence of twin studies and other inferential outcome investigations; (3) Describe the contribution of SmartTots to public and professional education; (4) Recognize the limits of the current data and outcomes to attribute causation; (5) Identify needs of future research questions; and (6) Provide commentary about the current FDA consensus statement.
Learn more about the IARS 2013 meeting and APSF panel.
Monday, December 17, 2012 | 3:45 – 5:00 PM
2012 PGA Annual Meeting, New York, NY
Hosted by the New York State Society of Anesthesiologists
Speakers: Drs. Jerrold Lerman and Linda Mason
Learner Objectives:
The participant will be able to:
- Discuss the animal data demonstrating negative effects of anesthetics on the developing brain;
- Discuss the current knowledge regarding the possible negative effect of anesthetics on the developing brain in humans;
- Discuss the areas of research to elucidate the effect of anesthetics on the developing brain;
- Discuss the ethical issues of not providing anesthetic care to infants;
- Advise parents about their childs impending surgery and anesthetic when asked about the effects of anesthesia on their child.
American Academy of Pediatrics National Conference & Exhibition (2012)
Saturday, 10/20/2012, 1:00 pm - 5:00 pm
Convention Center - Room 353-355
Description:
Analgesia, Sedation, and Withdrawal in the Neonatal Intensive Care Unit
Infants (term and preterm) in NICUs require long-term ventilation and intermittent procedures requiring sedation, analgesia, and anesthesia. Some Infants require ongoing opioid/sedative infusions for long periods, placing them at risk when these medications need to be withdrawn. Knowledge and practice gaps exist regarding safety of anesthetics for children in this age range as well as adequate monitoring during sedation. This session will deal with the physiologic and nonphysiologic assessment of pain in infants, the data on safety of anesthetic agents in infants, new developments in neonatal monitoring, and management of withdrawal.
Program Schedule:
1:00pm Welcome and Introduction
Moderators: John Zupancic, MD, ScD, FAAP; Carolyn Bannister, MD, FAAP
1:05pm Tolerance and Withdrawal of Neonatal Analgesic and Sedative Medications
Sunny Anand, MD, FAAP
1:35pm Procedural Sedation for Neonatal Intubation
Tom Mancuso, MD, FAAP
2:05pm Imaging Correlates of Neonatal Sedatives and Analgesics
Christopher McPherson, PharmD
2:35pm Break
2:50pm Safety of Operative Anesthesia
Lena Sun, MD, FAAP
3:20pm Long-Term Neurobehavioral Effects of Neonatal Pain and Its Treatment
Ruth Grunau, PhD
3:50pm Panel Discussion (All Presenters)
4:20pm Young Investigator Awards
Presenter: Sergio Golombek, MD
4:30pm Apgar Award Presentation
Recipient: Wally Carlo, MD
Presenter: Avroy Fanaroff, MD
American Academy of Pediatrics National Conference & Exhibition
Saturday, 10/20/2012; 4:00 pm - 5:30 pm
Hilton - Grand Ballroom A&B, New Orleans, LA
This session will feature international experts discussing the recent studies in infant rodent and nonhuman primates that have found evidence of neurotoxicity after exposure to anesthetic and sedative agents as well as the recent birth cohort studies that have shown a possible association with learning disabilities in children. The session will conclude with an extensive discussion of the implications of these studies on the current practice of anesthesia, procedural sedation, and surgery.
Moderator: Constance S. Houck, MD, FAAP
Faculty: Randall Flick, MD, FAAP and Sulpicio Soriano, MD, FAAP
Program Schedule:
4:00 PM Experimental Evidence for Neurotoxic Effects of Anesthetics and Sedative Agents in Young Animals
Sulpicio Soriano, MD, FAAP
4:30 PM Do Anesthetics and Sedative Agents Cause Neurotoxicity in Humans?
Randall Flick, MD, FAAP
5:00 PM Summary & Panel Discussion
Anesthesiologists: Constance S. Houck, MD, FAAP; Sulpicio Soriano, MD, FAAP; Randall Flick, MD, FAAP
Pediatric Surgeons:
Section on Otolaryngology & Head and Neck Surgery: Diego Preciado, MD, PhD, FAAP
Section on Orthopaedics: Brian Shaw, MD, FAAP
Section on Urology: Carlos Estrada, MD, FAAP
Section on Surgery: Shawn St Peter, MD, FAAP
5:30 PM Joint Surgical Reception
Visit the SmartTots booth at the Surgical Reception following the Joint Surgery Conference!
American Society of Anesthesiologists’ Anesthesiology 2012
Tuesday, Oct 16, 2012; 9:10 AM -10:00 AM
Location: 146C
Session Track: Obstetric Anesthesia (OB)
This RCL (given in 2008, 2009, 2010, and 2011 to date) reviews the effects of obstetric anesthesia on the baby. Topics discussed include: teratogenicity of anesthetic agents, overview of fetal/neonatal brain toxicity of general anesthetics, effect of regional anesthesia on maternal fever and possible fetal brain injury, and effect of labor epidural analgesia on breastfeeding success.
Learning Objectives:
1) State the effects of general and regional anesthetics on fetal development and the fetal brain.
2) Explain the areas of uncertainty regarding these effects.
Presenter:
Moderator
Scott Segal, M.D.
Tufts Medical Center Anesthesia Department, Boston, MA
American Society of Anesthesiologists’ Anesthesiology 2012
Monday, Oct 15, 2012; 1:30 PM - 3:00 PM
Location: 206
Session Track: Neuroanesthesia (NA)
This panel will provide an updated view of anesthesia and surgery neurotoxicity, with special emphasis on how to talk to patients about postoperative cognitive dysfunction.
Learning Objectives:
1) Discuss current clinical and basic research on anesthesia and surgery neurotoxicity.
2) Discuss risks of anesthesia and surgery on postoperative cognitive dysfunction with patients.
3) Evaluate potential prevention and treatment of postoperative cognitive dysfunction.
4) Synthesize information presented about the cellular and molecular mechanisms of anesthesia and surgery neurotoxicity.
Presentations:
Lead Speaker-Postoperative Cognitive Dysfunction: Can Anesthesia Play a Role?
Zhongcong Xie, M.D., Ph.D.
Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Speaker-Postoperative Cognitive Dysfunction: Can Surgery Play a Role?
Roderic G. Eckenhoff, M.D.
Anesthesia, University of Pennsylvania School of Medicine, Philadelphia, PA
Speaker-Maternal Anesthesia and Fetal Neurodevelopment
Arvind Palanisamy, M.D.
Anesthesia, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Speaker-Neonatal Anesthetic Neurotoxicity: What We Should Know
Greg Stratmann, M.D., Ph.D.
University of California at San Francisco, San Francisco, CA
American Society of Anesthesiologists’ Anesthesiology 2012
Monday, Oct 15, 2012; 11:30 AM - 1:00 PM
Location: 206
Session Track: Pediatric Anesthesia (PD)
This panel will provide an update and overview of the evidence suggesting a relationship between anesthetic exposure and neurologic injury in the laboratory and clinical setting.
Learning Objectives:
1) Identify the animal evidence for neurotoxicity of anesthetic agents.
2) Discuss evidence for neurotoxicity in young children.
Presentations:
Lead Speaker
Randall P. Flick, M.D., M.P.H.
Anesthesiology and Pediatrics, Mayo Clinic, Rochester, MN
Speaker-Of Mice and Monkeys: Neurotoxicity in Animals
Laszlo Vutskits, M.D.
Anesthesiology, University Hospital of Geneva, Geneva, Switzerland
Speaker-Clear as Mud: Evidence for Neurotoxicity in Children
Tom Hansen, M.D., PhD.
Anesthesia and Intensive Care, Odense University Hospital, Odense, Denmark
Speaker-Prospective Studies: The Holy Grail
Lena Sun, M.D.
Anesthesiology, Columbia University, New York, NY
Moderators: Zhiyo Zuo, MD, PhD; Frederico Bilotta, MD, PhD; Gregory Crosby, MD
SNACC 40th Anniversary Annual Meeting
Omni Shoreham Hotel, Washington, DC
October 12, 2012; 1:30 pm - 2:45 pm
Poster Session 2, Palladian Ballroom
98. Zheng Shaoqiang - The Effects of Sevoflurane on Apoptosis of Brain Cells and Learning Ability of Neonatal Rats
100. Ansgar Brambrink - Neuronal and Glial Apoptosis Observed Following Intravenous Propofol Anesthesia in Neonatal Macaques
Moderator: Peter J. Davis MD
Pro: Laszlo Vutskits MD, PhD; Con: Tom Hansen MD, PhD
SPA 2012 International Assembly for Pediatric Anesthesia
Marriott Wardman Park Hotel, Washington, DC
October 12, 2012 - 8:50-9:30 AM; Session 5: Ensuring Drug Safety
At the conclusion of this lecture participants will have learned of the clinical data relating to anesthetic related neurotoxicity in the young. Participants will also learn of the recommendations for and against practice change.
Presenter: Michael F. Roizen, MD
SPA 2012 International Assembly for Pediatric Anesthesia
Marriott Wardman Park Hotel, Washington, DC
October 12, 2012 - 8:10-8:40 AM; Session 5: Ensuring Drug Safety
At the conclusion of this lecture participants will have learned of SmartTots as it pertains to anesthetic related neurotoxicity in the young. Participants will also learn of the opportunities for research support and funding from SmartTots.
Euroanesthesia 2012
European Society of Anesthesiologists
Paris, France
June 11, 2012; 4-5:30pm
Moderators
Evers, Alex S.
Jevtovic-Todorovic, Vesna
Charlottesville, United States
Speakers
Anesthesia-induced developmental neurotoxicity: mechanism and protection
Jevtovic-Todorovic, Vesna, Charlottesville, United States
Anesthetic Related Neurotoxicity in Children: What do we tell the parents?
Flick, Randall, Rochester, United States
General anesthesia injures the developing brain of non-human primates
Brambrink, Ansgar, Portland, United States
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Sunday, May 20, 2012; 8-8:55am
Presenter: Peter J. Davis, MD, SmartTots Affiliate Advisory Council Member, Anesthesiologist-in-Chief, Children's Hospital of Pittsburgh, Professor of Anesthesiology & Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Learner Objectives: After participating in this activity, the learner will be able to: (1) Assess the issues of anesthesia related neurotoxicity in children; (2) Review the pathophysiology of sleep apnea in children; and (3) Review the anesthetic management of children with sleep apnea.
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Friday, May 18, 2012; 3-4:30pm
Speakers
Dhanesh K. Gupta, MD: The Pharmacy is out of Fentayl Again. What Do I Do?
Vesna Jevtovic-Todorovic, MD, PhD, MBA: Developmental Neurotoxicity: Are the Narcotics Safe?
Mohamed A. Naguib, MB, BCh, MSc, FFARCSI, MD: An Emerging Paradigm in Neuropathic Pain: Targeting the Inflamed Glial Cells
International Anesthesia Research Society 2012 Annual Meeting
Marriott Copley Place, Boston, Massachusetts
Sunday, May 20, 2012; 1-2:30pm
Moderator
Randall Flick, MD, MPH, Affiliate Advisory Council Member, SmartTots, Associate Professor of Anesthesiology, Mayo Clinic, Rochester, Minnesota
Panelists
Anesthesia and the Developing Brain: What are Our Options?
Vesna Jevtovic-Todorovic, MD, PhD, MBA, Scientific Advisory Board Member, SmartTots, Professor of Anesthesiology
and Neuroscience, University of Virginia Health System, Charlottesville, Virginia
Learner Objectives: After participating in this activity, the learner will be able to: (1) Identify the mechanisms responsible for anesthesia-induced developmental neurotoxicity; (2) Focus on most vulnerable cellular targets responsible for anesthesia-induced neuronal death; and (3) Assess possible protective strategies which would enable safe use of anesthesia in our youngest patients.
Preclinical Neurotoxicity Assessments of Pediatric Anesthetics: Translational Approaches Using a Nonhuman Primate Model
Merle Paule, PhD, Scientific Advisory Board Member, SmartTots and Director, Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas
Learner Objectives: After participating in this activity, the learner will be able to: (1) Describe the vulnerable periods during the rapid growth of the brain during which general anesthetics are likely to have their most deleterious effects in rodent and primate models of development; (2) Describe the duration (weeks, months, years) over which the adverse effects of developmental exposures to general anesthesia on cognitive function have been shown to manifest in animal models; and (3) Describe in general the kinds of cognitive deficits that have been observed in animal models after single, albeit prolonged, episodes of general anesthesia during the brain growth spurt.
Topic Title: TBD
Andrew J. Davidson, MBBS, MD, FANZCA, Affiliate Advisory Council Member, SmartTots, Department of Anaesthesia and Pain Management, The Royal Children’s Hospital Melbourne, Victoria, Australia
What is Needed to Resolve the Question of Whether Animal Studies Apply to Children?
David O. Warner, MD, Affiliate Advisory Council Member, SmartTots, Professor of Anesthesiology, Mayo Clinic, Rochester, Minnesota
Learner Objectives: After participating in this activity, the learner will be able to: (1) Articulate the concept of translation as applied to the relationship between model and human studies; (2) Analyze the strengths and weaknesses of various study designs in this area; and (3) Formulate a conceptual research agenda to resolve this question.
World Congress of Anaesthesiologists
World Federation of Societies of Anaesthesiologists
La Rural, Predio Ferial de Buenos Aires, Argentina
March 27, 2012; 11:00am-1:00pm
Chair and Introduction
Saager, Leif (USA)
Discussion
Absalom, Anthony (The Netherlands): Mechanisms of Neurotoxicity in the Developing Brain
Stapelberg, Francois (New Zealand): Measurements of Cognitive Function
Struys, Michel (The Netherlands): Delirium
EURO-NEURO 2012: 7th International Update on Interdisciplinary Neuroscience
Altes AKH - University of Vienna, Vienna, Austria
February 17, 2012; 9:00-10:30
Chairs
Peter Andrews, UK
Andrew Maas, Belgium
Speakers
Kristin Engelhard, Germany: Are Anesthetics Neurotoxic in Neonates?
Alfons Hammerle, Austria: Xenon and the Brain - Is there a Protective Effect?
Jonathan Rhodes, UK: Promising Neuroprotectants, particularly Progesterone
Pedro Amorim, Portugal: Cerebral Protection during Brain Surgery - Improvement of Current Models
World Congress of Anaesthesiologists
World Federation of Societies of Anaesthesiologists
La Rural, Predio Ferial de Buenos Aires, Argentina
March 27, 2012; 8:30-10:30 am
Chair
Eckenhoff, Roderic (USA)
Speakers
Developmental Neurotoxicity: Todorovic, Vesna (USA)
Calcium Dysregulation: Wei, Huafeng (USA)
Neuroinflammation: Eckenhoff, Roderic (USA)
Perioperative Tauopathy (neurodegenerative illnesses): Whittington, Robert (USA)
Anesthesiology 2011
American Society of Anesthesiologists
McCormick Place Complex, Chicago, Illionis
October 15, 2011; 2:45 PM - 4:45 PM
LEARNER OBJECTIVES:
- Describe the current clinical and preclinical research suggesting that anesthetic exposure may be toxic to the developing brain
- Review the perspective of the US. Food and Drug Administration and its role in ensuring the safety of anesthetic agents
- Discuss insight into potential changes in practice that may result from ongoing research and public concerns related to the safety of anesthetics in children
Moderator
Mervyn Maze, M.B., B.Ch.
University of California, San Francisco, San Francisco, California
Speaker-PreClinical/Clinical
Sulpicio G. Soriano, M.D.
Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts
Speaker-The FDA Perspective
Bob Rappaport, M.D.
Food and Drug Administration, Silver Spring, Maryland
Speaker-Does This Change Your Practice
Dean B. Andropoulos, M.D.
Texas Children's Hospital - Baylor College of Medicine, Houston, Texas
Society for Pediatric Anesthesia's 25th Annual Meeting
Hyatt McCormick Place, Chicago, Illinois
October 14, 2011; 1:30 - 3:00pm
The Past: Ether, Pancuronium and Oxygen
George Gregory, MD
- Understand the basis of modern anesthesia
- Recall how care then transitioned to present day care
- Discuss the history of some anesthetic drugs and anesthesia care
The Present: Inhalational - Neurotoxicity
Sol Soriano, MD
- Understand the sentinel laboratory reports that are the basis of anesthetic-induced developmental neurotoxicity
- Determine if the laboratory findings can be extrapolated to the care of pediatric patients
The Present: Opioids
Myron Yaster, MD
- Understand the neurobiology and neurophysiology of pain in the newborn
- Understand the use of opioids, local anesthetics, and vapors alone in combination in newborn anesthesia
The Future: Safe and Effective Alternatives for Sedation and General Anesthesia in Neonates
Mervyn Maze, MB, ChB
- Understand mechanism and uses for sedative properties of dexmedetomidine
- Understand mechanism and uses for xenon anesthesia
May 23, 2011; 1-4PM
Location
IARS
2011 Annual Meeting
Westin Bayshore Hotel
1601 Bayshore Drive
Vancouver, BC, V6G 2V4, Canada
Agenda
The panel, to be led by SmartTots Scientific Advisory Board Member Vesna Jevtovic-Todorovic, MD, PhD, will discuss recent studies relating to the effects of anesthetics on the developing brain and the potential implications of these findings. The Panel will be accompanied by poster presentations, including late-breaking abstracts.
Panel Speakers
Randall Flick, MD, MPH
Affiliate Advisory Board Member, SmartTots
Associate Professor of Anesthesiology
Mayo Clinic
Laszlo
Vutskits, MD, PhD
Head, Neuroscience-oriented Anesthesia Research Group
Staff Scientist, Pediatric Anesthesia Unit
Geneva University Hospital
Merle
Paule, PhD
Scientific Advisory Board Member, SmartTots
Director, Division of Neurotoxicology
National Center for Toxicological Research (NCTR)
Greg Stratmann, MD, PhD
IARS 2009 Clinical Scholar Research Award Recipient
University of California, San Francisco
March 10, 2011; 8AM – 4PM EST
Location
FDA White Oak Campus
Building 31, the Great Room
White Oak Conference Center (Rm. 1503)
10903 New Hampshire Avenue, Silver Spring, MD
Agenda
The committee will: (1) receive updates regarding neurodegenerative findings (findings related to degeneration in the nervous system) in juvenile animals exposed to anesthetic drugs, as well as results from human epidemiological studies using anesthesia in children (information related to studies of patterns and causes of disease); (2) discuss the relevance of these findings to pediatric patients and provide guidance for future preclinical and clinical studies; and (3) discuss the potential implications of these data upon the practice of pediatric anesthesia as well as the communication of the risk of sedative/anesthetic agents to prescribers and parents.
